Study of surufatinib, serplulimab, chemo for neuroendocrine carcinoma
Part of Cancer clinical trials.
This trial tests a combination of two targeted therapies (surufatinib and serplulimab) plus standard chemotherapy (platinum and etoposide) for people with a rare, aggressive type of cancer called neuroendocrine carcinoma that started outside the lung. The goal is to see if this new combination works better than chemotherapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of neuroendocrine carcinoma that started outside the lung (including mixed tumors with at least 30% neuroendocrine cells).
- You have not had any previous systemic therapy for this cancer.
- You are 18 years or older.
- You have at least one tumor that can be measured on scans.
- Your overall health is good (ECOG score 0 or 1).
- Your major organs (bone marrow, liver, kidneys) are functioning well enough, based on blood tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding chemotherapy to the drug surufatinib works better than surufatinib alone for people with a rare type of lung cancer called pulmonary neuroendocrine tumor. If you have this diagnosis and haven't had prior systemic treatment, you may be eligible.
This trial tests a combination of two drugs, surufatinib and serplulimab, for people with advanced solid tumors (like lung, stomach, or bowel cancer) that have stopped responding to standard treatments and have a specific cell change called neuroendocrine differentiation. The goal is to see if this new combination can help shrink tumors or slow their growth.
This trial tests a combination of targeted therapy (surufatinib), immunotherapy (serplulimab), and standard chemotherapy as a first treatment for advanced solid tumors that have neuroendocrine features. It aims to see if this combination can shrink tumors and improve outcomes for patients with certain cancers.
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