How bone exercise, alendronate, and diet affect bone strength
Part of Bones, joints & muscles, Hormones & metabolism clinical trials.
This trial studies whether doing a structured bone-focused exercise program, taking alendronate (a medication that slows bone loss), and making a calorie-reducing diet can improve bone strength in people with low bone density. It also compares different combinations to see what helps most and is safest for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Live in the community (not in a nursing home or similar facility)
- Have a body mass index (BMI) over 25, or over 25–30 with an added risk factor
- Have a recent routine dental check (at least annual care)
- Have low bone mass on a bone scan (T-score between -1.1 and -2.5 in key areas)
- Plan to attend study visits and be willing to be randomly assigned to a study group
- Must not have certain recent or planned dental work, major mobility limits, or recent major fractures/surgeries
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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