Tranexamic acid for bleeding after open nose surgery
Treatments studied
Part of Blood & lymphatic, Ear, nose & throat, Pain clinical trials.
This Phase 1 study tests whether tranexamic acid (a medicine that helps reduce bleeding) can lessen bleeding, swelling, and bruising after open rhinoplasty. You may be asked to take it around the time of surgery if you meet safety and lab criteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older and having open rhinoplasty (with bone repositioning) at VUMC with specific surgeons (Drs. Yang or Patel).
- Your surgery must not include other facial plastic procedures or sinus surgery at the same time.
- You cannot have a known allergy to tranexamic acid (TXA).
- You generally cannot have certain bleeding/clotting problems: prior blood clot (arterial or venous), current clotting disease, bleeding in the brain, low platelets, or known clotting disorders.
- You generally cannot take a blood thinner (anticoagulant) now, and must not have severe kidney problems or uncontrolled diabetes that would prevent steroid use around surgery.
- Your recent labs must meet thresholds (platelets at/above 150,000 and normal clotting timing such as PT and INR).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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