Prevent low blood pressure during dialysis by blocking bradykinin
Part of Heart & circulation, Kidney & urinary clinical trials.
This Phase 3 trial tests a medicine that blocks a body signal (bradykinin) to help prevent dangerous drops in blood pressure during hemodialysis. If you often get “intradialytic hypotension,” this study may help you dialyze more safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 to 80
- You have end-stage kidney disease and have been on hemodialysis (or hemodiafiltration) at least 6 months, about 3 times per week
- You’ve had at least 6 episodes of low blood pressure during dialysis in the last 8 weeks
- Your usual pre-dialysis systolic blood pressure is between 110 and 170 (on two average checks)
- Your dialysis is working well (Kt/V score is at least 1.2) and your dialysis settings/medicines haven’t changed in the last 14 days
- Your blood counts and liver tests are high enough (no very severe anemia, low platelets, or major liver enzyme/bilirubin problems)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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