CAR-T therapy for hard-to-control lupus
Treatments studied
Part of Immune system & allergy clinical trials.
This early-phase study tests a special immune therapy (CAR-T cells) made to target disease-driving immune cells in adults with lupus that has not improved despite standard treatments. It may offer a new option for people with severe, active lupus symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 70 years old
- Have severe lupus symptoms (a high lupus activity score) and meet lupus diagnosis rules
- Lupus must not respond well to at least two immunosuppressing medicines and/or one approved biologic for over 6 months
- Have certain blood counts in acceptable ranges (hemoglobin, white blood cells, neutrophils, and platelets)
- Have good heart function on an ultrasound test (ejection fraction at least 50%) and adequate kidney and liver function
- Be able to safely have cells collected from a vein (apheresis), with pregnancy prevention for women who can become pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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