CAR-T cell therapy for stubborn lupus kidney disease
Part of Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This trial tests a new treatment using your own immune cells (called CAR-T cells) that are modified to target two proteins (CD19 and BCMA) on lupus cells. It is for people with lupus nephritis (kidney inflammation) that has not improved after trying multiple standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have lupus nephritis (kidney inflammation from lupus) confirmed by a biopsy showing a specific type (Grade III, IV, or V).
- Your lupus is active (with a SLEDAI-2K score of 8 or higher at screening).
- At least two standard lupus treatments have not worked, or your lupus came back after treatment.
- You are willing to use birth control during the study and for 6 months after the cell infusion.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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