Gene therapy safety study for inherited high triglycerides and pancreatitis
Part of Genetic & congenital, Hormones & metabolism clinical trials.
This Phase 1 trial tests the safety of a gene therapy for people with inherited, hard-to-control high triglycerides (fat in the blood) who have had pancreatitis episodes. It may help by targeting the genes involved in triglyceride control, but the main goal here is to check safety and tolerability.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have inherited (genetic) high triglycerides that are not well controlled with usual treatment and diet.
- You have had pancreatitis at least once seriously, or pancreatitis episodes twice, within the last 5 years.
- Your fasting triglyceride level is above a set threshold (and you followed a low-fat diet before the blood test).
- Your genetic test shows a change in the GPIHBP1 or LPL gene (either one can qualify).
- If you can get pregnant, you must use reliable birth control starting before screening and continuing through the study (and for months after).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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