High-dose albumin for stubborn fluid buildup in liver disease
Treatments studied
Part of Digestive system clinical trials.
This Phase 2 trial tests whether high-dose albumin can reduce “refractory ascites,” which is fluid buildup in the belly that doesn’t improve with the highest tolerated water pills (diuretics). If you have liver cirrhosis and need frequent drainage, this study may offer a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be over 18 years old.
- You have been diagnosed with liver cirrhosis.
- You have refractory ascites, meaning your belly fluid hasn’t improved despite the highest tolerable doses of diuretics and you often need drainage (paracentesis).
- Your ascites should not be caused by heart problems or cancer.
- You should not have had a TIPS procedure (a liver-to-vein shunt) within the past 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a personalized long-term albumin (a blood protein medicine) can help people with advanced liver scarring who have fluid in the belly (ascites). It compares the personalized albumin approach to standard care to see if it improves outcomes over time.
This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.
This Phase 2 trial tests whether giving albumin together with enoxaparin (a blood thinner) can improve outcomes for people hospitalized with decompensated cirrhosis who are at high risk. It may help your recovery after certain serious liver-related complications and reduce the chance of poor outcomes.
This early-stage study tests a new medicine (GLR1075) that may help people with cirrhosis who have fluid in the belly (ascites) and low protein levels (hypoalbuminemia). The trial also checks the medicine in healthy volunteers to understand its safety and how the body processes it.
This study tests whether giving albumin through a vein helps people with cirrhosis who have a certain type of kidney problem (called acute kidney injury). The goal is to see if albumin works better than a simple saltwater solution in improving kidney function.
This trial tests whether giving human albumin through a vein can help people with liver cirrhosis who have confusion or drowsiness from a condition called hepatic encephalopathy. It is for patients with low albumin levels.
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