Clinical trials
Ascites clinical trials
Below are recruiting ascites clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03506893Recruiting
Alfapump device to reduce stubborn belly fluid in liver disease
This study looks at whether placing an Alfapump under the skin can better manage “refractory ascites,” which is stubborn belly fluid buildup in people with cirrhosis. It also evaluates the medical and economic impact of this care, and who benefits most.
AmiensAges 18 years+ - NCT05726747Recruiting
Quality-of-life study for fluid buildup and muscle loss
This trial studies people with recurring fluid buildup in the belly (ascites) and looks at how treatments or supportive care affect quality of life and muscle strength. It may help researchers better understand which approaches improve day-to-day well-being when ascites keeps coming back.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04835480RecruitingPhase 2
Study drug for swelling from advanced liver scarring
This Phase 2 trial tests OsrHSA in people with advanced cirrhosis who have swollen belly fluid (ascites). It aims to see whether the treatment can improve outcomes in this difficult liver condition.
Changchun, JilinAges 18–80 - NCT07855640Recruiting
Immunotherapy plus chemo for advanced stomach cancer with fluid in belly
This trial tests a new combination for advanced stomach cancer that has spread and caused fluid buildup in the belly (malignant ascites). It combines an immunotherapy drug (anti-PD-1) with standard chemotherapy and a targeted chemotherapy given directly into the belly to see if it can shrink the cancer and help you feel better.
Hangzhou, ZhejiangAges 18–75 - NCT06433869RecruitingPhase 2
Three-drug combination for malignant ascites from digestive cancers
This trial tests three drugs (bevacizumab, serplulimab, and rmhTNF-NC) given together to treat fluid buildup in the belly caused by digestive system cancers. It’s for people whose ascites has not improved after standard treatments.
Guangzhou, GuangdongAges 18 years+ - NCT06658080Recruiting
Testing drugs on fluid from breast cancer
This trial uses fluid from the chest or belly of breast cancer patients to grow tiny tumor models in the lab. These models help doctors find which drugs might work best for each patient.
Hangzhou, ZhejiangAges 18–70 - NCT07490626Recruiting
Home paracentesis for cancer-related fluid buildup
This study tests whether patients with cancer-related belly fluid can safely have their fluid drained at home instead of at a clinic. If it works, it could make treatment more convenient and comfortable.
Salt Lake City, UtahAges 18 years+ - NCT07435701RecruitingPhase 1/Phase 2
Cell injection into belly for advanced ovarian cancer with fluid buildup
This trial tests a new type of therapy where special cells (called SK-NK cells) are injected directly into the belly to treat fluid buildup (ascites) caused by advanced ovarian cancer. It is for patients whose cancer has not responded to at least two prior treatments and who have no other standard options left.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07397819RecruitingPhase 1/Phase 2
Liposomal Irinotecan for Malignant Ascites
This trial tests a drug called liposomal irinotecan, given alone or with other medications, to treat fluid buildup in the belly caused by digestive system cancers. It's for people who have already tried standard treatments without success.
Guangzhou, GuangdongAges 18 years+ - NCT07378436RecruitingEarly Phase 1
Testing a new drug for cancer-related belly fluid
This early-phase trial tests an experimental drug called GK02 for people with advanced cancer who have fluid buildup in the belly (malignant ascites). The drug is given directly into the belly to try to reduce the fluid and control symptoms.
BeijingAges 18–75 - NCT06812390RecruitingPhase 2
Albumin plus diuretics for cirrhosis-related leg swelling
This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.
West Haven, ConnecticutAges 18 years+ - NCT07007988RecruitingPhase 1
SIM0388 for fluid buildup in the abdomen from cancer
This trial tests a new drug, SIM0388, for people whose cancer has spread and caused fluid buildup in the belly. It aims to see if the drug is safe and can help reduce the fluid.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06995846Enrolling by invitation
Testing bacterial DNA in belly fluid to diagnose SBP in cirrhosis
This study tests a new way to detect bacteria in the fluid in your belly (ascites) to see if it can quickly diagnose a serious infection called spontaneous bacterial peritonitis (SBP) in people with cirrhosis. If you have cirrhosis and ascites, this trial may help improve how fast infections are found.
BeijingAges 18 years+ - NCT06814626RecruitingPhase 3
Nutrition therapy for muscle loss in cirrhosis with fluid buildup
This trial tests whether a special nutrition plan can help treat muscle loss in people with liver cirrhosis who also have fluid buildup that doesn't improve with standard treatment. It aims to improve strength and outcomes after a procedure to place a shunt in the liver.
PalermoAges 18–80 - NCT06759064RecruitingPhase 1/Phase 2
Intraperitoneal Immunotherapy and Bone Drug for Stomach Cancer Belly Fluid
This trial tests a combination of two drugs—one that helps your immune system fight cancer (immune checkpoint inhibitor) and one that strengthens bones (zoledronic acid)—given directly into the belly (intraperitoneal) to control fluid buildup caused by stomach cancer. It may help people with moderate to severe malignant ascites who have not had local belly treatments or immunotherapy recently.
Jinan, ShandongAges 18–75 - NCT06576934Recruiting
Early TIPS for liver cirrhosis with ascites
This study tests whether placing a small tube (called a TIPS) early in the liver can help people with cirrhosis who have their first episode of moderate to severe belly fluid buildup. The goal is to see if this early procedure improves outcomes compared to standard care.
Freiburg im BreisgauAges 18–80 - NCT05867602RecruitingPhase 2
High-dose albumin for stubborn fluid buildup in liver disease
This Phase 2 trial tests whether high-dose albumin can reduce “refractory ascites,” which is fluid buildup in the belly that doesn’t improve with the highest tolerated water pills (diuretics). If you have liver cirrhosis and need frequent drainage, this study may offer a new treatment option.
Houston, TexasAges 18 years+ - NCT05745233Enrolling by invitation
Testing immune therapy put into the belly for cancer fluid
This trial studies whether an immune-blocking drug placed directly into the belly cavity can help people with cancer-caused fluid buildup (malignant ascites) from stomach, pancreas, or bile-duct cancers. It may help shrink the fluid and slow the illness, but you must meet specific safety and treatment-history requirements.
Taichung, Please SelectAges 20 years+ - NCT05056220RecruitingPhase 3
Albumin treatment for advanced cirrhosis with fluid buildup
This trial tests whether a personalized long-term albumin (a blood protein medicine) can help people with advanced liver scarring who have fluid in the belly (ascites). It compares the personalized albumin approach to standard care to see if it improves outcomes over time.
LeuvenAges 18 years+ - NCT03020979RecruitingPhase 2
Apatinib for fluid buildup in the belly from cancer
This trial tests a pill called apatinib in people whose cancer has spread to the belly and causes fluid to build up (malignant ascites). Apatinib works by cutting off the blood supply that tumors need to grow, which may help reduce the fluid and ease symptoms.
Bengbu, AnhuiAges 18–75 - NCT04767945Recruiting
Cirrhosis patient hospital registry
This study keeps a record of people who have liver cirrhosis and were admitted to the hospital after a worsening event. It may help doctors better understand what leads to hospital stays and improve future care.
Banská BystricaAges 19 years+ - NCT01789229Recruiting
Tumor and inflammation sample bank for one specific condition
This study builds a secure “tumor sample bank” using tissue collected from people who currently have one diagnosed condition, either cancer (malignant disease) or an ongoing inflammatory condition. Your samples could help researchers study your disease and develop better treatments in the future.
ViennaAges 18 years+ - NCT07794787Recruiting
Predicting kidney problems in liver cirrhosis with fluid buildup
This study aims to create a formula to predict which patients with liver cirrhosis and fluid in the belly might develop kidney issues. It uses routine lab tests to help doctors identify risks early and plan better care.
New Delhi, National Capital Territory of DelhiAges 18–65 - NCT07684326RecruitingPhase 2/Phase 3
Can dapagliflozin help liver cirrhosis with fluid buildup? (Phase 2/3 randomized trial)
This trial tests a diabetes pill (dapagliflozin) to see if it helps people with liver cirrhosis and fluid buildup (ascites). The goal is to improve fluid balance and possibly reduce hospital stays.
GizaAges 18 years+
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Common questions
- Are there clinical trials for ascites?
- Yes. Clin2 currently lists 47 recruiting ascites studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ascites trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ascites trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.