Oral cancer treatment with chemo, then surgery and radiation
Part of Cancer clinical trials.
This trial studies giving chemotherapy first, then removing the tumor with surgery and follow-up radiation for certain cases of oral squamous cell carcinoma. It may help shrink and control the cancer before and after surgery, depending on how well the tumor can be fully removed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a new diagnosis of squamous cell carcinoma of the mouth (confirmed by biopsy).
- Your cancer is in specific mouth areas (tongue, floor of mouth, gums, inner cheek, or back of the roof of mouth).
- Your stage is advanced (Stage III or Stage IVB) with no distant spread (M0).
- Your cancer can be fully removed by surgery after chemo (or fully removable after initial assessment).
- You are well enough for treatment: your general health score is 0–1.
- You can do required scan tests to check for distant metastasis (like CT/PET-CT or bone scan), and you agree to follow-up and study visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving radiation therapy after surgery, adjusted based on how the cancer responds, can improve outcomes for people with advanced head and neck cancer. It may help reduce side effects while keeping the treatment effective.
This trial compares two types of neck surgery to treat certain early-stage oral squamous cell cancers that have lymph node involvement. It may help doctors choose the safest approach and potentially reduce unnecessary treatment while still controlling the cancer.
This trial tests a combination of low-dose radiation and an immunotherapy drug (similar to Keytruda) given before surgery for advanced head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.
This trial tests whether adding targeted radiation (SBRT) to a combination of chemotherapy and immunotherapy before surgery can improve outcomes for people with advanced mouth or throat cancer. It aims to shrink the tumor more effectively before removal.
This study compares ways of treating early squamous cell cancer in the tonsil or the tongue base, using either radiation therapy, transoral (through-the-mouth) surgery, or both. It aims to see which approach works best while keeping cancer under control.
This trial compares two approaches for treating oral cancer: having surgery right away or having chemotherapy first followed by surgery. It aims to find which sequence leads to better outcomes for patients.
Hear when a new Oral Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.