Clin2
NCT04224389Possibly a fitRecruiting

Radiation plus throat surgery for early tonsil or tongue-base cancer

Squamous Cell Carcinoma

Part of Cancer clinical trials.

This study compares ways of treating early squamous cell cancer in the tonsil or the tongue base, using either radiation therapy, transoral (through-the-mouth) surgery, or both. It aims to see which approach works best while keeping cancer under control.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
150 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You must be 18 or older
  • Your cancer must be squamous cell cancer in the oropharynx (tonsil area or tongue base)
  • Your tumor should be early stage: T1–T2 and no or limited neck lymph node spread (N0–N1)
  • You must be well enough to do daily activities (rated 0–2) and be able to attend follow-up visits
  • Your medical team must have p16 or HPV (virus) test results for your tumor
  • You must be able to undergo or complete the planned radiation follow-up and complete questionnaires

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT02128906Recruiting· Phase 2
Radiation plus chemo choices for throat cancer, using a tumor marker

This trial compares two treatment combinations given with radiation for certain cancers of the throat. It also uses a lab test on the tumor (ERCC1) to help choose and study which treatment works better.

Pittsburgh, Pennsylvania
NCT05144100Not yet recruiting· Phase 2/Phase 3
Surgery versus chemoradiation for tonsil and tongue-base cancer

This trial compares two standard treatments for a type of throat cancer (oropharyngeal cancer) that has not spread to distant organs. Patients will be randomly assigned to either surgery or a combination of chemotherapy and radiation, to see which approach offers better outcomes.

Mumbai, Maharashtra
NCT07402525Recruiting
Radiation after surgery for early-stage tongue cancer with risk factors

This trial tests whether adding radiation therapy after surgery helps prevent the return of early-stage tongue cancer in patients who have certain risk factors, such as nerve invasion or poorly differentiated cells. It is for people whose cancer was limited to the front two-thirds of the tongue and was completely removed.

Bengbu, Anhui
NCT06485778Recruiting· Phase 2
Radiation after surgery for early-stage oral tongue cancer

This trial tests whether giving radiation after surgery can lower the risk of the cancer coming back for people with oral tongue cancer that has specific high-risk features but not advanced spread. It aims to find the best treatment plan for patients with certain tumor characteristics.

Basking Ridge, New Jersey
NCT04220749Recruiting· Phase 2
Radiation vs mouth surgery for HPV-negative throat cancer

This Phase 2 trial compares two standard cancer treatments—radiation or surgery through the mouth—for HPV-negative oropharyngeal throat cancer. It aims to find out which approach works better while keeping side effects and quality of life acceptable.

London, Ontario
NCT07402538Not yet recruiting· Phase 3
Comparing surgery with and without pre-surgery treatment for mouth or throat cancer

This study compares doing surgery alone versus giving a combination of focused radiation (SBRT) and chemotherapy with an immunotherapy drug before surgery for mouth or throat cancer. The goal is to see if the pre-surgery treatment makes the cancer shrink more and improves outcomes.

Guangzhou, Guangdong

Hear when a new Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.