Chemoimmunotherapy with or without radiation before surgery for advanced mouth and throat cancer
Part of Cancer clinical trials.
This trial tests whether adding a type of radiation therapy (SBRT) to chemoimmunotherapy before surgery helps people with advanced mouth or throat cancer. The goal is to see if this combination can shrink tumors more effectively and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have squamous cell carcinoma of the mouth or throat that can be removed with surgery.
- Your cancer is stage III or IVa, meaning it is locally advanced but has not spread to distant parts of the body.
- You are between 18 and 65 years old.
- You are generally healthy and able to care for yourself (ECOG score 0 or 1).
- Your blood counts, liver, kidney, and clotting function are within acceptable ranges.
- You have not had certain prior treatments, including immunotherapy with drugs like toripalimab or anti-PD-1/PD-L1 antibodies.
- You do not have active autoimmune diseases, HIV, hepatitis B or C, or active tuberculosis.
- You are not pregnant or breastfeeding, and you agree to use effective contraception during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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