Total treatment with tailored radiation for advanced rectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a “total neoadjuvant” approach—chemotherapy first, then radiation—using adaptive (tailored) radiation planning for people with locally advanced rectal cancer. It may help improve tumor control while adjusting the radiation based on how your cancer and anatomy respond.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have locally advanced rectal cancer with specific high-risk features (like T4a, threatened/close margins, certain lymph node involvement, or blood-vessel involvement).
- You have not had any prior treatment for rectal cancer.
- You have not had radiation to the same area before (for example, radiation for the prostate).
- You can do MRI scans (no MRI safety issues or metal/conditions that prevent MRI).
- Your overall health score is ECOG 0 or 1 (you are able to function fairly well).
- You cannot be pregnant, and you must be willing and able to sign consent; you also must be able to take the study drugs (5-FU, capecitabine, and oxaliplatin).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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