5-HTP and creatine for adults with depression symptoms
Part of Mental health clinical trials.
This Phase 2 study tests whether adding 5-HTP and creatine can reduce depression symptoms in adults with major depressive disorder. It may help if your current depression treatment hasn’t been fully effective and you meet the safety and medical criteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18–65 years old
- You have a current diagnosis of major depressive disorder (MDD) confirmed by an interview (MINI)
- Your depression symptom score (HAM-D17) is 16 or higher
- You have taken an FDA-approved antidepressant in the SSRI/SNRI family for at least 8 weeks and can show good adherence
- You do not have certain medical conditions (kidney disease, certain bowel problems, uncontrolled lung disease, significant heart rhythm risk, seizures)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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