Ultrasound with carboplatin for recurrent glioblastoma
Treatments studied
Part of Cancer clinical trials.
This trial tests a device that opens the blood-brain barrier using ultrasound, allowing chemotherapy to reach the brain tumor better. It compares this approach to standard chemotherapy for people whose glioblastoma has returned.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a glioblastoma brain tumor that has come back after initial treatment
- You had surgery or biopsy and standard radiation therapy for your first treatment
- You received at least one line of chemotherapy or other therapy after radiation
- The tumor is in an area that can be mostly removed with surgery (at least 50%)
- You are well enough to have surgery and are 18 or older
- Your blood counts and liver/kidney function are within acceptable limits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding the Optune device (a wearable electric field therapy) to standard chemotherapy (temozolomide) and the immunotherapy drug pembrolizumab can help people with newly diagnosed glioblastoma live longer. You may be able to join if you've completed initial radiation and chemo, and have not received certain immunotherapies before.
This trial tests a combination of focused ultrasound and the immunotherapy drug pembrolizumab for people whose glioblastoma has returned after standard treatment. The ultrasound may help the drug work better by temporarily opening the blood-brain barrier.
This trial tests a new approach that combines a drug (SONALA-001 or 5-ALA) with focused ultrasound to treat glioblastoma that has come back or is growing despite standard treatments. The drug makes tumor cells sensitive to sound waves, and the ultrasound waves are directed at the tumor using MRI guidance. This may help damage cancer cells while sparing healthy brain tissue.
This trial tests a combination of MRI-guided laser surgery, a wearable device (Optune) that sends electric fields to the brain, and an immunotherapy drug (pembrolizumab/Keytruda) for people whose glioblastoma has come back. The goal is to see if this approach is safe and works better than standard treatments.
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
This trial tests a device that uses focused ultrasound to help the drug bevacizumab (Avastin) better reach brain tumor cells. It is for people with glioblastoma that has come back after standard treatments like radiation and temozolomide.
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