Venetoclax plus azacitidine versus stronger chemotherapy for AML
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 2 trial compares two treatment approaches for people newly diagnosed with a specific type of AML (bone marrow cancer) that has an NPM1 mutation: venetoclax plus azacitidine versus intensive (strong) chemotherapy. It aims to see which plan works better and is safer for “fit” patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You will sign informed consent and can understand study instructions
- You have newly diagnosed AML that is CD33-positive and has an NPM1 mutation
- You are age 18 to 70, and are considered fit for intensive chemo (ECOG 0–2)
- Your liver, kidney, and overall health test results are within required limits
- Your white blood cell count is under 25,000/µL (a medicine like hydroxyurea is allowed to lower it)
- You have not had prior AML treatment other than hydroxyurea, and you have not had venetoclax or azacitidine before
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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