Cariprazine alone for major depression symptoms
Treatments studied
Part of Mental health clinical trials.
This Phase 4 trial tests how well cariprazine works by itself to reduce symptoms of major depressive disorder (MDD). You may be eligible if you’re currently in a depressive episode and your depression score stays within a certain range at both screening and study start.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with major depressive disorder (MDD) and are in a current depressive episode, confirmed by a structured interview (MINI).
- Your depression severity score (MADRS) is at least 26 at both screening and start, with no more than 20% improvement between those visits.
- If you can become pregnant, you must have a negative urine pregnancy test and agree to reliable birth control during the study.
- You must be able to understand the study and follow its rules, as judged by the study team.
- You must not have a history of psychosis, schizophrenia, or bipolar disorder.
- You must not have previously not responded to or not tolerated cariprazine/other antipsychotic medicines, and you must not take interacting antipsychotic medications during the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a personalized approach to treating major depressive disorder using assessments and brain imaging to match you with the best therapy. It aims to improve outcomes by tailoring care to your specific needs.
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
This trial compares lithium versus cariprazine to treat an episode of depression in people with bipolar disorder. It may help find which medicine works better and is safer during the acute (active) phase of depression.
This trial tests a monthly injection of cariprazine (a medication for mental health conditions) in people who could benefit from it. It aims to see if the shot is safe, tolerable, and effective compared to taking pills every day.
This trial tests whether cariprazine works and is safe for teens aged 13 to 17 with schizophrenia. It may help if your symptoms are still moderate to severe despite current care.
This study compares two medications, Lumateperone and Cariprazine, to see which works better and has fewer side effects for people with bipolar I depression. It may help find a more effective treatment for your depressive symptoms.
Hear when a new Depressive Disorder, Major trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.