Switch from anti-C5 shots to iptacopan for aHUS
Treatments studied
Part of Blood & lymphatic, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether people with atypical hemolytic uremic syndrome (aHUS) who are doing well on anti-C5 treatment can safely switch to iptacopan. It focuses on both effectiveness (blood counts and kidney function) and safety after the switch.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult (18+) with a confirmed diagnosis of aHUS, and other similar kidney conditions have been ruled out
- Have been taking anti-C5 antibody treatment on the usual recommended schedule for at least 3 months before screening
- Show signs of response during screening, including normal-ish platelets and stable kidney function over the screening period
- Be willing to get required meningitis/pneumonia vaccines before starting iptacopan
- Not have had a relapse of aHUS while on anti-C5 treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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