Skipping axillary lymph node surgery after treatment response
Part of Cancer, Skin clinical trials.
This study looks at whether some breast cancer patients can safely skip a surgery that removes lymph nodes in the armpit after their initial (pre-surgery) treatment shows the armpit is likely clear. It may reduce surgical side effects if the armpit truly responds well.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are assigned female at birth and are between 18 and 70 years old
- Your breast cancer has been confirmed by pathology and is in stage T1 to T3
- Before treatment, your armpit lymph nodes were found to be positive (N1 to N3), and you had full pre-surgery treatment
- After treatment, your doctor believes the armpit has turned negative (ycN0), and you meet the study’s armpit mapping/sampling steps using carbon nanoparticles
- Your health status is good enough for the trial (ECOG score 0 to 1), and you can commit to planned follow-up and treatment afterward
- You meet key medical lab/heart/bleeding requirements and do not have certain exclusions (like pregnancy/lactation, prior cancers, prior armpit surgery, or distant metastases)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies whether you can safely avoid a lymph node biopsy in the armpit for early breast cancer when scans and exams look negative. It may reduce surgery-related side effects while still keeping cancer care on track.
This trial tests whether it's safe to skip armpit surgery in people whose breast cancer has responded well to chemotherapy and whose lymph nodes appear cancer-free on ultrasound. It aims to reduce side effects like arm swelling while still controlling the cancer.
This trial tests whether it is safe to skip removing lymph nodes from the armpit when cancer has spread there but has been found by ultrasound. If you have breast cancer that has spread to armpit lymph nodes and are not getting chemotherapy before surgery, this study may be an option.
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This study looks at whether it’s safe and effective to avoid removing many underarm lymph nodes in some people who, after chemotherapy, still seem to have only tiny (“micro”) cancer deposits in the sentinel lymph node. It may help reduce treatment side effects while keeping cancer control.
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