SGLT2 inhibitor for metabolic syndrome and heart health
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests whether a diabetes medication called an SGLT2 inhibitor can reduce inflammation in body fat and improve blood vessel function in people with metabolic syndrome. It may help prevent heart disease and other complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You need to have metabolic syndrome, which is having at least three of these: high blood pressure, high triglycerides, low HDL (good) cholesterol, high blood sugar, or a large waist size.
- Your body mass index (BMI) must be 35 or higher.
- If you have type 2 diabetes, it must be well-controlled (HbA1c less than 9%) and you can only take metformin or a sulfonylurea (stable dose).
- You must not have certain health conditions like heart disease, stroke, pancreatitis, or kidney problems.
- You must not be pregnant or breastfeeding, and if you can have children, you need to use birth control.
- You must not have certain urinary or genital issues or be at high risk for them.
- You must not take anticoagulants or loop diuretics.
- You must not drink more than 14 alcoholic drinks per week (men) or 7 per week (women).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if empagliflozin, a medication typically used for diabetes, can help people with metabolic syndrome (a cluster of conditions like large waist size, high blood sugar, and high blood pressure). It may improve health and reduce the risk of heart disease.
This trial tests if empagliflozin, a diabetes medicine, can improve weight and metabolism in people with HIV who take dolutegravir and have a high body mass index (BMI). It may help reduce weight gain linked to HIV treatment.
This trial tests if metformin helps people with metabolic syndrome, a cluster of conditions like high blood pressure, high blood sugar, high cholesterol, and belly fat. It may improve overall metabolic health.
This trial tests whether an SGLT2 inhibitor (a type of diabetes medication) can help reduce stiffness in the arteries of veterans who have obesity. If you are a veteran aged 30-60 with a BMI of 30-45 and have stiffer arteries than expected for your age, this study might be an option.
This trial tests how stopping a type 2 diabetes medication called an SGLT2 inhibitor affects the liver's production of sugar and ketones. It may help understand better ways to manage diabetes.
This study tests whether a medication called empagliflozin (a diabetes drug) can improve heart function in older adults with high blood pressure and obesity who are at risk for heart failure but do not have it yet. You would take the pill daily and have heart ultrasounds to check your heart's health.
Hear when a new Obesity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.