Personalized treatment for advanced head and neck cancer
Treatments studied
Part of Cancer, Ear, nose & throat clinical trials.
This trial tests a custom treatment plan for people with advanced head and neck cancer that is not caused by HPV. It combines radiation and chemotherapy with a targeted drug called cetuximab, adjusted based on your tumor's characteristics.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have head and neck cancer that has spread to nearby areas but not to distant organs.
- Your cancer is HPV-negative and at stage III or IV.
- You have not had radiation or chemotherapy for head and neck cancer before.
- You have not had complete surgical removal of the cancer within the last 8 weeks.
- You are in good overall health with normal organ function (kidneys, liver, blood counts).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether adding a checkpoint immunotherapy (tislelizumab) and a cancer pill (pamiparib) to radiation can better treat cancer that has come back in the head and neck. It’s for adults with previously treated, HPV-positive oropharynx tumors, usually without widespread spread.
This trial combines immunotherapy with a special type of radiation that spares healthy lymph nodes, aiming to boost the body's immune response against the tumor. It is for patients with certain types of head and neck cancer that have not spread too far and can be surgically removed.
This trial compares two treatments for advanced head and neck cancer in patients who cannot take the drug cisplatin. One group gets radiation plus a targeted drug called cetuximab, the other gets radiation plus standard chemotherapy. The goal is to see which approach works better and is safer for people who are not candidates for cisplatin.
This study tests a new treatment approach for head and neck cancer that can't be removed with surgery. You would get a combination of an immunotherapy drug (which helps your immune system fight cancer) and chemotherapy first, followed by the standard chemoradiation therapy.
This trial tests a combination of chemotherapy directly into an artery, radiation, and immunotherapy for advanced head and neck cancer. It may offer a new treatment option for people whose cancer hasn't spread to other parts of the body.
This study tests whether adding the chemotherapy drug paclitaxel (Taxol) to the targeted therapy cetuximab (Erbitux) is more effective than cetuximab alone for head and neck cancer that has progressed after initial immunotherapy and chemotherapy. Researchers want to see if the combination can help shrink tumors or slow the disease.
Hear when a new HPV-Negative Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.