Targeted pill combination for BRAF-mutated metastatic colorectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a combination of two targeted pills (tunlametinib and vemurafenib) for people with metastatic colorectal cancer that has a specific gene change (BRAF V600E) and whose cancer has grown after at least one prior treatment. The goal is to see if this drug combination can shrink tumors or slow cancer growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced colorectal cancer that has spread to other parts of the body and has the BRAF V600E gene change.
- You have already tried at least one prior treatment for your metastatic cancer and it didn't work or stopped working.
- You are between 18 and 70 years old and in fairly good health (able to do light activity).
- You haven't taken any BRAF or MEK inhibitor drugs before.
- You don't have serious heart, liver, kidney, bleeding, or stomach problems that would prevent you from taking the study pills.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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