Drug combo for BRAF-mutated advanced colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of four drugs (irinotecan liposome, fluorouracil, folinic acid, vermofenib, and cetuximab) as a first treatment for people with advanced colorectal cancer that has a specific BRAF V600E mutation. It aims to see if this combination can shrink tumors or slow their growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced colorectal cancer that has spread or cannot be removed by surgery.
- Your tumor has a specific gene change called BRAF V600E.
- You have not had any treatment for advanced disease, or your cancer came back more than 12 months after finishing adjuvant therapy.
- You are between 18 and 80 years old and able to care for yourself (ECOG score 0-2).
- You have at least one measurable tumor on scans, and you are not pregnant (if applicable).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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