Study of three drugs for advanced colorectal cancer after first treatment
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of three drugs (irinotecan liposomes, cetuximab, and vemurafenib) for people with advanced colorectal cancer that has a specific genetic change (BRAF V600E mutation) and did not respond to first treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have colorectal cancer that has spread and has a specific genetic change called 'RAS wild-type and BRAF V600E mutation'
- Your first standard treatment (including chemo with oxaliplatin or irinotecan) did not work or caused side effects you couldn't tolerate
- You have at least one tumor that can be measured on scans
- You are generally able to take care of yourself (ECOG score 0-2)
- Your blood counts and organ function (kidney, liver) are within acceptable ranges
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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