A study of ALETA-001 for certain B-cell blood cancers
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a new treatment called ALETA-001 for people with B-cell non-Hodgkin lymphoma that has come back or not responded to previous treatments, including CAR T-cell therapy. It aims to see if ALETA-001 can help when standard options have not worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 16 years or older with a confirmed diagnosis of B-cell non-Hodgkin lymphoma.
- You need to have tried a standard anti-CD19 CAR T-cell therapy and either had a partial response, stable disease, or relapsed within 9 months (for some groups).
- You must be well enough to be up and about (ECOG performance status 0, 1, or 2).
- Your blood tests must be within certain limits (like red and white blood cells, platelets).
- You cannot have serious ongoing side effects from previous treatments or active infections.
- You must be willing to follow contraception rules if you or your partner can have children.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1/2 study tests a lab-made immune cell treatment (CAR T cells) made from your own blood cells to treat aggressive large B-cell lymphoma that has come back or didn’t respond. If you qualify, the goal is to see whether this treatment is safe and can shrink lymphoma.
This trial tests a new treatment called ALA-101 for people with certain types of blood cancers (lymphoma and leukemia) that have a protein on the cancer cells called CD19. The treatment aims to target and destroy these cancer cells, potentially helping patients who have not responded to other therapies.
This early-phase trial tests an injected “CAR T” cell therapy made to attack CD19-positive blood cancers that have come back or did not respond. If you qualify, the study checks whether the treatment can help control the cancer and is safe enough to study further.
This trial tests a new treatment called GI001 for people with B-cell lymphoma or B-cell leukemia that has come back or hasn't responded to previous treatments. It aims to see if GI001 can help when other options have failed, and it may be an option if you haven't had CAR-T therapy before.
This trial tests a new type of CAR-T cell therapy for people with certain B-cell lymphomas that have come back or not responded to treatment. The CAR-T cells are made from a donor and are genetically edited to possibly work better and last longer.
This trial tests a new type of cell therapy that targets two markers (CD19 and CD20) on lymphoma cells. It is for patients whose lymphoma has come back or has not responded to standard treatments.
Hear when a new Large B-cell Lymphoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.