Zimberelimab with chemo before surgery for cervical cancer
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial tests a combination of immunotherapy (zimberelimab) and chemotherapy before surgery for locally advanced cervical cancer that has not spread far. It aims to shrink the tumor to make surgery more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cervical cancer that is squamous cell, adenocarcinoma, or adenosquamous type.
- Your cancer is locally advanced (stage IB3 or IIA2) and has not been treated before.
- You are at least 18 years old and female.
- You have a tumor that can be measured and you are willing to provide a tissue sample for PD-L1 testing.
- Your overall health is good (ECOG score 0 or 1) and your organ function is near normal.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests two immunotherapy drugs (iparomlimab and tuvonralimab) combined with chemotherapy before surgery for locally advanced cervical cancer. It aims to shrink tumors and improve outcomes for patients who haven't had prior systemic treatment.
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This study tests a new drug called zimberelimab, which helps the immune system fight cancer, after standard radiation and chemotherapy for cervical cancer. It might improve the chances of keeping the cancer from coming back.
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