Clin2
NCT07876154Possibly a fitRecruiting

Immunotherapy plus chemo before surgery for locally advanced cervical cancer

Locally Advanced Cervical Cancer

Treatments studied

This trial tests a new combination of two immunotherapy drugs with standard chemotherapy before surgery for cervical cancer that has not spread far. The goal is to shrink the tumor and improve treatment outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
34 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • You are a woman aged 18 to 70.
  • You have a certain type of cervical cancer (squamous cell, adenocarcinoma, or adenosquamous).
  • Your cancer is at stage IB3 or IIA2 and you have not had any prior cancer treatment.
  • You are generally healthy and able to perform daily activities (ECOG score 0 or 1).
  • Your blood tests show adequate kidney, liver, and blood cell counts.
  • You can provide a tumor tissue sample for testing.
  • If you could become pregnant, you must agree to use effective birth control and not breastfeed.
  • You do not have active autoimmune disease, severe infection, or certain heart or lung conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06055738Recruiting· Phase 2
Zimberelimab with chemo before surgery for cervical cancer

This trial tests a combination of immunotherapy (zimberelimab) and chemotherapy before surgery for locally advanced cervical cancer that has not spread far. It aims to shrink the tumor to make surgery more effective.

Xi'an, Shaanxi
NCT07055399Recruiting· Phase 2
Neoadjuvant immunotherapy with two drugs plus chemo for cervical cancer

This trial tests two immunotherapy drugs (iparomlimab and tuvonralimab) combined with chemotherapy before surgery for locally advanced cervical cancer. It aims to shrink tumors and improve outcomes for patients who haven't had prior systemic treatment.

Fuzhou, Fujian
NCT06288373Recruiting· Phase 2/Phase 3
Comparing chemoimmunotherapy vs chemoradiation for advanced cervical cancer before surgery

This trial tests whether a combination of chemotherapy and immunotherapy (pembrolizumab) before surgery works better than standard chemoradiation for locally advanced cervical cancer. It may help shrink tumors more effectively.

Hefei, Anhui
NCT07104149Recruiting· Phase 2
Chemo plus immunotherapy before surgery for cervical cancer

This trial tests adding a new immunotherapy drug (cadonilimab) to standard chemotherapy before surgery for locally advanced cervical cancer. The goal is to see if this combination helps shrink the tumor more effectively before surgery.

Zhengzhou, Henan
NCT06288360Recruiting· Phase 2
Chemo plus immunotherapy before surgery for PD-L1-negative cervical cancer

This trial tests whether combining chemotherapy with immunotherapy before surgery can help treat cervical cancer that is PD-L1 negative. It's for women with larger tumors (stage IB3 to IIB) who have not been treated yet.

Hefei, Anhui
NCT07232654Recruiting· Phase 2
Immunotherapy plus chemoradiation for advanced cervical cancer

This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemoradiation for locally advanced cervical cancer caused by HPV. It may be an option for women with stage 3-4A disease or positive lymph nodes who have not had immunotherapy before.

Beijing

Hear when a new Locally Advanced Cervical Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.