Elacestrant alone or with a CDK4/6 inhibitor for advanced breast cancer
Part of Cancer, Skin clinical trials.
This trial compares a new hormone therapy (elacestrant) to the same therapy combined with a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) for people with a specific type of advanced breast cancer (ER-positive, HER2-negative) that has a mutation in the ESR1 gene. It aims to see if the combination works better than the single drug.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your breast cancer is ER-positive (more than 10% of cells show estrogen receptors) and HER2-negative.
- You have a mutation in the ESR1 gene (confirmed by standard tests from your medical records).
- You have at least one tumor that can be measured on scans, or a bone lesion that has lost calcium.
- You have already tried at least 2 hormone therapies, including a CDK4/6 inhibitor, for metastatic disease.
- You are 18 years or older and have good overall health (ECOG score 0 or 1).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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