Capacitabine with or without elacestrant for ER+ breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests if adding a new oral targeted therapy (elacestrant) to standard chemotherapy (capecitabine) works better than chemotherapy alone for people with a specific type of advanced breast cancer that is hormone-sensitive (ER-positive) and has stopped responding to hormone therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced (metastatic or locally recurrent) breast cancer that is estrogen receptor-positive (ER+) and HER2-negative.
- You have had at least one prior hormone therapy for advanced disease, or you relapsed during or within a year of finishing adjuvant hormone therapy.
- You have a specific ESR1 or TP53 gene mutation in your tumor, confirmed by a blood or tissue test.
- You have not had chemotherapy for advanced breast cancer before (prior hormone therapy and CDK4/6 inhibitors are allowed).
- You can swallow pills and have adequate organ function (kidney, liver, blood counts).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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