Infliximab for depression with cognitive problems
Treatments studied
Part of Mental health clinical trials.
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 25 and 50 years old.
- You need a diagnosis of major depression, with moderate symptoms (a score of 15 or higher on a depression rating scale).
- A blood test must show that you have a certain level of inflammation (C-reactive protein at least 3 mg/L).
- You cannot have taken antidepressant medication for at least 4 weeks before the study, or you must be on a stable dose that you don't change during the study.
- You cannot have certain medical conditions like active infections, cancer, autoimmune diseases, or a history of stroke affecting your thinking.
- You must be willing to have an IV infusion and blood draws, and not start any new treatments during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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