Adding roflumilast to antidepressants for depression
Treatments studied
Part of Mental health clinical trials.
This study tests if adding roflumilast, a medicine that reduces inflammation, can help people with major depression feel better when taken with their current antidepressant. It is for adults with moderate to severe depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You must have moderate to severe depression, with a Hamilton Depression Rating Scale (Ham-D) score of at least 18.
- You cannot have bipolar disorder, eating disorders, personality disorders, or substance abuse within the last 3 months.
- You cannot be pregnant or planning to become pregnant without using birth control.
- You cannot have serious thoughts of suicide (rated 3 or more on the Ham-D suicide item).
- You must be able to stop other psychiatric medications (except for escitalopram and anti-inflammatory drugs) for 4 weeks before the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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