Clin2
NCT06136988Possibly a fitNot yet recruiting

Chemotherapy and radiation for advanced esophageal cancer

Locally Advanced Unresectable Esophageal Squamous Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a new combination of chemotherapy drugs and radiation for advanced esophageal cancer that cannot be removed with surgery. The goal is to see if this treatment can help shrink the cancer and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
129 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You must have a type of esophageal cancer called squamous cell carcinoma that is locally advanced and cannot be surgically removed.
  • You must be able to perform daily activities with minimal assistance (ECOG score 0-1).
  • Your organs (like kidneys, liver, and blood) must be functioning well enough to tolerate the treatment.
  • You must not have had prior treatment for esophageal cancer.
  • You must be willing to use effective birth control during the study and for 6 months after the last dose.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06491134Not yet recruiting· Phase 1
Chemotherapy plus radiation for advanced esophageal cancer

This trial tests a new combination of two chemotherapy drugs (liposomal irinotecan and cisplatin) given together with radiation therapy for locally advanced esophageal cancer. It aims to see if this treatment is safe and effective, potentially offering a new option for patients who cannot have surgery.

NCT07622797Recruiting· Phase 2
Immunotherapy with chemotherapy and radiation for esophageal cancer

This trial tests a new immunotherapy drug (camrelizumab) combined with standard chemotherapy and radiation to treat advanced esophageal cancer while avoiding surgery if possible. The goal is to shrink the tumor and help you keep your esophagus working.

Luoyang, Henan
NCT07530094Recruiting· Phase 2
Radiation and chemotherapy with immunotherapy for advanced esophageal cancer

This trial tests a combination of radiation, chemotherapy (cisplatin and paclitaxel), and an immunotherapy drug called camrelizumab for patients with advanced esophageal squamous cell carcinoma that cannot be surgically removed. The goal is to see if adding immunotherapy improves outcomes compared to standard treatment alone.

Nanjing, Jiangsu
NCT06122493Recruiting· Phase 2
Better treatment for advanced esophageal cancer

This trial tests a new treatment plan for people with advanced esophageal squamous cell carcinoma that has spread to lymph nodes but not to other organs. It aims to find the best way to treat this cancer using radiation and other therapies.

Shanghai, Shanghai Municipality
NCT07435454Recruiting· Phase 2
Oral paclitaxel plus radiation for advanced esophageal cancer

This trial tests a combination of an oral chemotherapy drug (paclitaxel) and radiation therapy for people with advanced esophageal cancer that cannot be removed by surgery. It may be an option if you are 70 or older or cannot tolerate IV chemotherapy and have trouble swallowing.

Nanjing, Jiangsu
NCT06173986Recruiting· Phase 1/Phase 2
Immunotherapy plus chemoradiation for advanced esophageal cancer

This trial tests whether adding immunotherapy to standard chemoradiation can help people with unresectable locally advanced esophageal cancer. It aims to improve outcomes for those who cannot have surgery.

Shanghai

Hear when a new Locally Advanced Unresectable Esophageal Squamous Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.