Raludotatug Deruxtecan for resistant ovarian cancer
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This study tests a new drug called Raludotatug Deruxtecan (R-DXd) for people with ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The goal is to see if R-DXd can shrink tumors or slow cancer growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You have a type of ovarian, primary peritoneal, or fallopian tube cancer that is high-grade and has stopped responding to platinum-based chemotherapy.
- You have had at least 1 but no more than 3 (for Phase 2) or 4 (for Phase 3) prior cancer treatments, including at least one that included bevacizumab (unless you can't take it).
- You have at least one tumor that can be measured on a CT or MRI scan, and you are willing to have a biopsy (for Phase 2).
- You are in good enough health to perform daily activities with little or no help (ECOG performance status 0 or 1).
- You must not have had certain other cancers, uncontrolled heart or lung problems, or active infections like HIV or hepatitis B/C.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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