PLX038 for brain tumors with MYC or MYCN changes
Part of Brain & nervous system, Cancer clinical trials.
This study tests a new drug called PLX038 for people with brain or spinal cord tumors that have certain genetic changes (MYC or MYCN) or have come back after treatment. The drug is given as an infusion and targets tumor cells. The study aims to see if the drug is safe and effective for different types of these tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a primary brain or spinal cord tumor that has come back or is growing.
- For some parts of the study, the tumor must have a specific genetic change (MYC or MYCN amplification).
- You are 18 years or older.
- You are generally able to care for yourself (Karnofsky score 70% or higher).
- You have had a break from prior treatments like chemotherapy or radiation (at least 4 weeks, sometimes longer).
- You have tumor tissue available for testing, or you are willing to have a biopsy if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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