Clin2
NCT06190847Worth exploringRecruiting

Oral bacteria and response to chemoradiotherapy in esophageal cancer

Esophageal Squamous Cell CarcinomaChemoradiotherapyInitial Inoperable

Part of Cancer, Digestive system clinical trials.

This study looks at how the bacteria in your mouth might affect how well chemoradiotherapy (a combination of chemotherapy and radiation) works for esophageal cancer that cannot be removed by surgery. The goal is to see if the oral microbiome can predict treatment response.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
97 people
Ages
18 years to 85 years
Study type
Observational

Who can take part

  • You are between 18 and 85 years old.
  • You are able to do most of your daily activities without help (ECOG score 0-2).
  • You have been diagnosed with squamous cell carcinoma of the esophagus.
  • Your tumor is at a stage that cannot be removed with surgery right now (cT2-4aN0-3M0).
  • You have not had any chemotherapy, radiation, or other cancer treatment before.
  • You are willing to provide a signed consent form.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06602843Recruiting
Chemoimmunotherapy before and after surgery for esophageal cancer

This trial tests a treatment plan that combines chemotherapy and immunotherapy before surgery, followed by radiation and immunotherapy after surgery for people with esophageal squamous cell cancer. It aims to see if this approach helps prevent the cancer from coming back.

Hefei
NCT06509568Recruiting· Phase 2
Chemoradiation plus immunotherapy before surgery for esophageal cancer

This trial tests giving a combination of chemotherapy, radiation therapy, and an immunotherapy drug before surgery for a type of esophageal cancer (squamous cell). The goal is to see if this approach helps shrink the tumor and improve outcomes for patients whose cancer can be surgically removed.

Hangzhou, Zhejiang
NCT04460352Recruiting· Phase 3
Esophageal cancer treatment with chemoradiation plus planned surgery

This trial tests the best way to treat locally advanced squamous cell esophageal cancer: either chemoradiation followed by planned surgery, or monitoring with surgery only if needed. It may help you choose a strategy that controls the cancer while aiming to reduce unnecessary procedures.

Montreal, Quebec
NCT04328948Recruiting· Phase 3
Preventive radiation for early esophagus cancer after chemoradiation

This Phase 3 trial tests whether giving preventive (prophylactic) radiation reduces cancer coming back in people with early esophagus cancer after standard chemoradiation. It may help by lowering the chance that microscopic cancer spreads to nearby areas.

Tokyo
NCT06561178Recruiting
Blood Test to Monitor Esophageal Cancer After Surgery

This trial looks at whether a personalized blood test can detect cancer returning after surgery for esophageal cancer. It tests people who had chemoradiotherapy before surgery and still had some cancer remaining in the removed tissue. The goal is to use the blood test to catch any remaining or returning cancer early.

Guangzhou, Guangdong
NCT07111455Recruiting
Oral bacteria changes with chemoimmunotherapy for mouth cancer

This study is testing whether a combination of chemotherapy and immunotherapy before surgery can help treat advanced oral cancer. Researchers will also look at how the cancer changes the bacteria in your mouth.

Guangzhou, Guangdong

Hear when a new Esophageal Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.