Clin2
NCT06201065Possibly a fitRecruiting

Targeted therapy and immunotherapy for advanced liver cancer

Hepatocellular Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of two drugs (lenvatinib and toripalimab, a type of immunotherapy) plus a special chemotherapy infusion directly into the liver artery for people with advanced liver cancer that has not been treated before. The goal is to see if adding the immunotherapy helps shrink tumors better than the standard combination.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
200 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You have advanced liver cancer (stage C) that cannot be removed with surgery or cured with other treatments.
  • You have never received any treatment for your liver cancer before.
  • Your liver is working well enough (no fluid in the belly, no dangerous bleeding, no confusion, and your blood tests are within safe limits).
  • You are in fairly good overall health (able to care for yourself and do light activity).
  • You do not have HIV, a history of organ transplant, or active bleeding problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07594340Recruiting· Phase 3
Advanced Liver Cancer Treatment Comparison Study

This study compares two treatment approaches for advanced liver cancer that has spread within the liver but not to other parts of the body. Both treatments combine chemotherapy delivered directly to the liver with immunotherapy drugs to help your immune system fight the cancer.

Guangzhou, Guangdong
NCT03899428Recruiting· Phase 2
Immune therapy versus targeted therapy for advanced liver cancer

This trial compares an immune “checkpoint” medicine to a targeted cancer medicine in people with advanced liver cancer who have hepatitis B in the blood. It aims to lower hepatitis B surface antigen (HBsAg) levels and see which approach works better and is safest.

Hong Kong, Hong Kong SAR
NCT05062837Recruiting· Phase 2/Phase 3
Surgery plus two drugs for advanced liver cancer

This trial combines surgery to remove liver tumors with two drugs, camrelizumab (an immunotherapy that helps your immune system fight cancer) and apatinib (a targeted therapy that may cut off the tumor's blood supply). It aims to see if this combination helps people with advanced liver cancer that has spread outside the liver (but not to the brain) and who have chosen not to have other standard treatments like TACE or radiation. Participating could potentially control the spreading cancer and improve outcomes.

Nanning
NCT07786792Not yet recruiting
Targeted therapy and immunotherapy for advanced liver cancer

This study is testing whether combining targeted therapy with immunotherapy (or using two immunotherapies together) can help people with liver cancer that cannot be surgically removed. The goal is to understand how well these treatments work and how they affect biomarkers (signals in your body that show treatment response).

NCT05718232Not yet recruiting· Phase 3
Focused radiation plus targeted therapy for advanced liver cancer

This trial tests a combination of a focused radiation beam (SBRT) plus a pill that helps stop tumor blood vessel growth (lenvatinib) and a procedure that blocks blood flow to the tumor (TACE) for people with advanced liver cancer that has not yet spread outside the liver. The goal is to see if this triple therapy can improve outcomes without prior treatment.

Guangzhou, Guangdong
NCT07192185Recruiting· Phase 2
Chemo plus immunotherapy for advanced liver cancer after first treatment fails

This trial tests a new combination of chemotherapy (FOLFOX) plus atezolizumab and bevacizumab for people with advanced liver cancer that has grown after having atezolizumab and bevacizumab alone. The goal is to see if adding chemo helps stop the cancer from growing further.

Guangzhou, Guangdong

Hear when a new Hepatocellular Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.