Trastuzumab Deruxtecan for HER2-positive stomach cancer with remaining cancer after surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests if trastuzumab deruxtecan, a targeted drug, can help people with HER2-positive stomach or gastroesophageal junction cancer who still have cancer cells detected after surgery and chemotherapy. It aims to prevent the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had surgery to remove your stomach or gastroesophageal junction cancer after receiving FLOT chemotherapy.
- Your tumor is HER2-positive (a specific protein on cancer cells) and a blood test after surgery showed cancer DNA still present.
- You are 18 or older, able to care for yourself (ECOG 0-1), and expected to live at least 3 months.
- Your heart function is normal (LVEF of 50% or more) and your kidney, liver, and blood counts are adequate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at how well the drug trastuzumab deruxtecan (T-DXd) works and how safe it is in people with advanced HER2-positive stomach or gastroesophageal junction cancer in China. It may be an option if you have already had other treatments.
This trial tests a new targeted drug (TDXd) combined with chemotherapy, pembrolizumab, and trastuzumab for people with HER2-positive stomach or gastroesophageal junction cancer that has spread or cannot be removed by surgery. It aims to see if this combination works better than standard treatments as a first therapy.
This trial tests two drugs, disitamab vedotin and trastuzumab, for people with HER2-positive stomach or gastroesophageal junction cancer that has spread or come back after at least one prior treatment. The goal is to see if this combination can help shrink tumors.
This trial tests whether a targeted drug called trastuzumab deruxtecan can help people with advanced HER2-positive stomach, esophageal, or gastroesophageal junction cancer. It's for those who haven't had chemotherapy for metastatic disease and are not able to get combination therapy.
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