CAR-T cells for autoimmune diseases
Part of Immune system & allergy clinical trials.
This trial tests a new CAR-T cell therapy that targets two immune proteins (CD19 and BAFF) to treat autoimmune diseases like lupus or scleroderma. It is for people who have not improved with standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older with a diagnosed autoimmune disease (such as lupus, kidney inflammation, scleroderma, dermatomyositis, or neuromyelitis optica).
- Your disease must still be active after trying at least two standard treatments (like steroids, immune suppressants, or biologics) for over 6 months, or you must have no good treatment options after remission.
- You need to have enough white blood cells, red blood cells, and platelets (laboratory tests will confirm).
- You cannot have serious heart, kidney, or liver problems, active infections (like HIV, hepatitis B or C), or a history of seizures or stroke.
- If you are of childbearing age, you must use effective birth control for at least 6 months after the final treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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