Clin2
NCT06289062Possibly a fitRecruiting

Chemo plus camrelizumab before surgery for stage IB1 cervical cancer

Cervical CancerNeoadjuvant ChemoimmunotherapyFertility Preservation

Treatments studied

Part of Cancer, Women’s health & pregnancy clinical trials.

This trial tests whether giving chemotherapy combined with camrelizumab (a drug that helps the immune system fight cancer) before surgery can help women with early-stage cervical cancer who want to preserve their fertility. It is for patients whose tumors show a protein called PD-L1.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
18 years to 45 years
Study type
Interventional

Who can take part

  • You have stage IB1 cervical cancer (confirmed by exam and MRI).
  • Your cancer type is squamous cell carcinoma (the most common type).
  • Your tumor has a protein called PD-L1 (a score of CPS 1 or higher).
  • You are between 18 and 45 years old and have a strong desire to get pregnant in the future.
  • You are in generally good health (able to do daily activities, good blood counts, and no active autoimmune diseases).
  • You have not had chemotherapy, radiation, or other immune drugs before.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06289751Recruiting· Phase 2
Chemo-immunotherapy before surgery for stage IB2 cervical cancer

This trial tests if giving chemotherapy plus an immunotherapy drug before surgery can help shrink tumors and improve outcomes for patients with stage IB2 cervical cancer that has not been treated yet. It might be an option if you have a specific type of cervical cancer that shows a certain protein (PD-L1) on your tumor cells.

Wuhan, Hubei
NCT06288360Recruiting· Phase 2
Chemo plus immunotherapy before surgery for PD-L1-negative cervical cancer

This trial tests whether combining chemotherapy with immunotherapy before surgery can help treat cervical cancer that is PD-L1 negative. It's for women with larger tumors (stage IB3 to IIB) who have not been treated yet.

Hefei, Anhui
NCT06288373Recruiting· Phase 2/Phase 3
Comparing chemoimmunotherapy vs chemoradiation for advanced cervical cancer before surgery

This trial tests whether a combination of chemotherapy and immunotherapy (pembrolizumab) before surgery works better than standard chemoradiation for locally advanced cervical cancer. It may help shrink tumors more effectively.

Hefei, Anhui
NCT06209294Recruiting· Phase 2
New drug combo before fertility-sparing surgery for cervical cancer

This trial tests a combination of immunotherapy (AK104) and standard chemotherapy before surgery for a certain type of early-stage cervical cancer. The goal is to see if this approach can help shrink the tumor enough to allow fertility-preserving surgery, so you may be able to keep your uterus.

Shanghai, Shanghai Municipality
NCT07167160Recruiting· Phase 2
Chemo-immune therapy for stage IIICp cervical cancer

This trial tests a combination of chemotherapy and immunotherapy for patients with cervical cancer that has spread to pelvic lymph nodes (stage IIICp) after radical surgery. It aims to improve outcomes by boosting the immune system's ability to fight remaining cancer cells.

Hangzhou, Zhejiang
NCT04016389Recruiting
Neoadjuvant chemo then fertility-sparing surgery for cervical cancer

This study looks at whether giving chemotherapy before surgery (neoadjuvant chemotherapy) can shrink certain cervical cancers enough to allow fertility-sparing surgery. It may help some people avoid removing the uterus, while still treating the cancer effectively.

Houston, Texas

Hear when a new Cervical Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.