Chemotherapy before surgery for colon cancer in older adults
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether giving 6 weeks of chemotherapy (FOLFOX) before surgery can help people aged 70 and older with locally advanced colon cancer. It aims to make treatment safer and more effective for older adults.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 70 years or older.
- You have a type of colon cancer (called adenocarcinoma) that has not spread to other organs but is considered locally advanced.
- Your tumor has a normal DNA repair system (called MSS or pMMR).
- You are healthy enough to receive 6 weeks of chemotherapy (FOLFOX) before surgery, as decided by your doctors.
- You have not had a complete bowel blockage or any other serious medical condition that would make the trial unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving chemotherapy before surgery can improve outcomes for people with colon cancer that has grown into nearby tissue or lymph nodes but hasn't spread to other organs. It is for patients whose tumors are mismatch repair proficient (pMMR) or microsatellite stable (MSS).
This trial tests whether giving chemotherapy before surgery helps people with colon cancer that caused a blockage and needed a temporary colostomy. It aims to improve outcomes compared to standard treatment.
This trial tests whether using a ctDNA blood test can help choose the best chemotherapy after colon cancer surgery for people aged 70–80. It aims to make treatment more personalized and reduce side effects.
This Phase 3 trial studies whether giving chemotherapy after surgery helps people age 70+ with stage III colon cancer. You would be compared to another planned treatment approach, aiming to lower the chance of the cancer coming back.
This trial tests two chemotherapy drugs, capecitabine alone or with oxaliplatin, in people aged 70 or older after surgery for stage III colorectal cancer. The goal is to find out which treatment works better to prevent cancer from coming back.
This trial tests whether a stronger chemo combination plus an immunotherapy drug (PD-1 inhibitor) works better than standard chemo alone when given before surgery for locally advanced colon cancer. It aims to shrink the tumor and improve outcomes.
Hear when a new Colon Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.