Checking the best pre-surgery treatment for rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 3 trial compares different chemotherapy and radiation combinations given before surgery for locally advanced rectal cancer, to see which one works better. It may help people get a tumor removed completely (R0 resection) and improve outcomes while comparing treatment safety and effectiveness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 75 years old
- Have rectal adenocarcinoma (a type of rectal cancer) confirmed by biopsy
- Your tumor is locally advanced (not spread far away), and a scan suggests it can be fully removed with surgery
- No current bowel blockage, or any blockage improves after a temporary/near-term colostomy
- You have not had rectal surgery, chemotherapy, or radiation before (endocrine therapy is allowed)
- Be well enough for treatment (ECOG 0–1) and have enough major organ function (bone marrow, liver, kidneys)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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