Combination therapy for advanced bile duct cancer
Part of Cancer clinical trials.
This trial tests a combination of two drugs (surufatinib and toripalimab) plus a chemotherapy infusion directly into the liver artery (HAIC) for people with bile duct cancer that cannot be removed by surgery or has spread. The goal is to see if this combination can shrink tumors or slow the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have intrahepatic cholangiocarcinoma (bile duct cancer in the liver) that cannot be removed with surgery or has spread to other parts of the body.
- Your liver function is good (Child-Pugh grade A).
- You have not received any systemic treatment for this cancer, unless you had chemotherapy as part of an earlier treatment plan and it ended more than 6 months ago.
- You have at least one tumor that can be measured on a scan and has not been treated with local therapies like radiation.
- You do not have active infections like hepatitis B or C, HIV, or autoimmune diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new combination of three drugs (adebrelimab, surufatinib, and liposomal irinotecan) given directly into the liver artery for advanced intrahepatic cholangiocarcinoma. The goal is to see if this approach can shrink or control the cancer.
This study tests a combination of liver-directed therapy (D-TACE-HAIC), an immunotherapy drug (Envafolimab), and a targeted therapy pill (Lenvatinib) for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be surgically removed. The goal is to see if this combination can shrink or control the cancer.
This Phase 3 study tests whether toripalimab (an immunotherapy) combined with lenvatinib and chemotherapy works better than standard treatment for advanced intrahepatic cholangiocarcinoma. It aims to help people live longer and/or control the cancer more effectively.
This trial tests a combination of chemotherapy directly into the liver artery, an immunotherapy drug, and a targeted therapy pill before surgery for a type of bile duct cancer that has a high chance of coming back. The goal is to see if this approach can improve outcomes for patients whose cancer is still removable but has certain high-risk features.
This trial tests a combination of a targeted drug (lenvatinib), an immunotherapy (PD-1 inhibitor), and chemotherapy given directly into the liver's blood supply for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer that starts in the liver). The goal is to see if this combination can shrink tumors or slow the cancer's growth.
This trial looks at a combined treatment for a large, inoperable type of liver cancer (intrahepatic cholangiocarcinoma). It uses chemotherapy delivered directly into the liver, plus a targeted pill (lenvatinib) and an immunotherapy drug (PD-1 inhibitor) to try shrink the tumor and improve outcomes.
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