Studying a drug to improve walking in peripheral artery disease
Part of Heart & circulation clinical trials.
This trial tests whether a drug called diroximel fumarate (Vumerity) can improve blood flow and walking ability in people with peripheral artery disease (PAD). It compares people with PAD to healthy volunteers of the same age.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 50 and 75 years old.
- You have been diagnosed with PAD and have leg pain when walking that goes away with rest (claudication).
- You are not pregnant or nursing, and if female, you have not had a period for more than 24 months.
- Your kidney and liver function are normal based on recent blood tests.
- You do not have other conditions like multiple sclerosis, psoriasis, or inflammatory bowel disease.
- You are not taking dimethyl fumarate or have an allergy to diroximel fumarate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a personalized exercise program for people with peripheral arterial disease (PAD), a condition that causes leg pain when walking. The goal is to see if a tailored exercise plan can help reduce pain, improve walking distance, and boost quality of life.
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
This trial checks how well a device called the Pantheris Small Vessel System works to treat blocked small blood vessels in the foot/leg. It may help people improve circulation, but you must meet specific health and follow-up requirements.
This trial tests whether a home-based exercise program is as effective as supervised exercise for improving walking ability in people with peripheral artery disease (PAD). You will be randomly assigned to one of two exercise groups, and you may be asked to drink beetroot juice as part of the study.
This study tests whether a special “drug-eluting” stent placed in a leg artery works safely and improves blood flow for people with peripheral artery disease. It may help reduce re-narrowing and improve walking, depending on your blockage details and overall health.
This study tests whether a community-based exercise program helps people recover and improve walking after a procedure to restore blood flow in the leg arteries. It may help if your main problem is leg circulation problems and you’re able to take part in exercise safely.
Hear when a new Peripheral Artery Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.