Whole-body hyperthermia for depression
Part of Mental health clinical trials.
This trial tests whether safely raising your body temperature (whole-body hyperthermia) can help relieve depression. It's for people with moderate to severe major depression who are not currently taking antidepressants.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depression and it is your main mental health issue.
- Your depression is moderate to severe (scoring 14 or higher on a specific depression scale).
- You are able to speak and understand German fluently.
- You are not currently taking any antidepressant or mood-stabilizing medication (or have stopped for at least 2 weeks, 8 weeks for fluoxetine/Prozac).
- You do not have certain health conditions that affect body temperature control, like heart disease, diabetes with nerve damage, or a history of stroke or seizures.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether controlled whole-body heat can change immune-related brain and body signals in people with major depressive disorder. It may help researchers understand why heat affects mood and who might benefit, while closely monitoring safety.
This study tests whether combining whole-body heat therapy (using a sauna-like device) with an online mental health program can help reduce depression symptoms. Researchers want to see if heating your body in a controlled way, along with digital therapy tools, works better together for depression.
This trial tests whether a special light you can use at home can help treat major depression. It's a 60Hz light that you turn on and off repeatedly. If you're 24–65, have depression, and take a stable antidepressant, you may be able to participate.
This study tests whether shining near-infrared light through the head can change brain blood flow and reduce depression symptoms. If you have major depression, you may be offered a non-drug, device-based approach to see how well it helps.
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
This trial tests if a 12-week exercise program can reduce inflammation and improve brain function in people with depression. It's for adults currently taking antidepressant medication and looking for extra help through physical activity.
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.