Clin2
NCT05487911Likely a fitRecruiting

Brain stimulation for depression

Major Depressive DisorderOpioid Use DisorderSuicidality

Part of Mental health clinical trials.

This study uses a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to treat depression. It may help reduce depressive symptoms for people who have not found relief from other treatments.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
50 people
Ages
18 years to 64 years
Study type
Interventional

Who can take part

  • You must be between 18 and 64 years old.
  • You must have symptoms of depression as measured by a standard questionnaire.
  • You must be able to have an MRI (no metal implants, pacemaker, or other unsafe items).
  • You must be able to have TMS (no non-removable metal in or near your head).
  • If you are female, you cannot be pregnant or breastfeeding.
  • You must be stable on your current medications and have a negative urine test for opioids.
  • You must speak and understand English.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07842601Not yet recruiting
Brain stimulation for depression and opioid addiction

This study tests whether brain stimulation can help with both depression and opioid cravings in people who are already taking buprenorphine for opioid addiction. It may offer an extra tool to improve your mood and reduce cravings.

Lexington, Kentucky
NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression

This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.

Toronto, Ontario
NCT07512284Recruiting· Phase 2
Mindfulness and Brain Stimulation for Treatment-Resistant Depression

This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.

San Diego, California
NCT05489042Recruiting
Brain scan and rTMS study for suicidal thoughts in opioid users

This study looks at brain connectivity using an MRI scan and then treats some people with rTMS (a non-surgical brain stimulation). It’s designed for adults who use opioids and currently have active suicidal thoughts, to better understand and help those symptoms.

Houston, Texas
NCT07804459Not yet recruiting· Early Phase 1
Personalized brain stimulation for depression

This study uses brain imaging to guide a noninvasive treatment called transcranial magnetic stimulation (TMS) for people with depression. It aims to see if tailoring the stimulation to each person's brain can improve symptoms.

Philadelphia, Pennsylvania
NCT06152705Recruiting
fMRI-Guided vs. Standard Brain Stimulation for Depression

This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.

Ottawa, Ontario

Hear when a new Major Depressive Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.