Large neutral amino acids for adults with classical PKU
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study tests whether a specific mix of large neutral amino acids (LNAAs) can help adults with classical PKU by lowering phenylalanine levels in the brain. It includes an MRI and PET scan to see how the treatment affects brain activity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have been diagnosed with classical PKU (a severe type of phenylketonuria).
- You started PKU treatment within the first month of life and followed the special diet until at least age 15.
- You have an IQ above 84 based on a recent test.
- You are not taking sapropterin (BH4) or Pegvaliase (PALYNZIQ) and have no metal implants or other MRI restrictions.
- You are not pregnant, breastfeeding, or planning pregnancy, and you weigh under 110 kg (about 242 pounds).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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