Clin2
NCT06387420Possibly a fitNot yet recruiting

Study of AK117 with azacitidine and venetoclax for acute myeloid leukemia

ACUTE MYELOID LEUKEMIA; AML

Treatments studied

Part of Blood & lymphatic, Cancer clinical trials.

This trial tests a new drug called AK117 combined with two standard treatments (azacitidine and venetoclax) for people with acute myeloid leukemia (AML). The goal is to see if this combination is safe and effective in treating the disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
180 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You must have a diagnosis of acute myeloid leukemia (AML).
  • You must be able to perform daily activities (with some help if needed) and have a life expectancy of at least 12 weeks.
  • Your organs (like liver and kidneys) must be functioning well enough.
  • If you can become pregnant or father a child, you must agree to use effective birth control during the study and for 120 days after the last dose.
  • You cannot have certain other types of leukemia or have had a stem cell transplant before.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06773208Recruiting· Phase 2
Azacitidine and venetoclax for people with AML in remission

This trial tests a combination of two drugs, azacitidine and venetoclax, for people with acute myeloid leukemia (AML) who have achieved remission after initial chemotherapy but still have tiny amounts of leukemia cells left (measurable residual disease). The goal is to see if this treatment can clear those remaining cells before a stem cell transplant.

Basking Ridge, New Jersey
NCT07743112Recruiting· Phase 2
Study of a new drug combo for untreated acute myeloid leukemia

This trial tests a new drug, MAX-40279, combined with two standard treatments (venetoclax and azacitidine) for people with newly diagnosed acute myeloid leukemia who are not healthy enough for intensive chemotherapy. The goal is to see if adding this drug improves outcomes.

Tianjin
NCT07490288Recruiting
Venetoclax, azacitidine, and mitoxantrone for new AML

This trial tests a combination of three drugs (venetoclax, azacitidine, and liposomal mitoxantrone) as a first treatment for people newly diagnosed with acute myeloid leukemia (AML). The goal is to see if this combination works better than standard care.

Tianjin, Tianjin Municipality
NCT06196203Recruiting· Phase 2
Study of AK117 with Azacitidine for High-Risk MDS

This trial tests a new drug, AK117, combined with azacitidine for people newly diagnosed with high-risk myelodysplastic syndromes (MDS), a blood disorder. The goal is to see if the combination can help improve outcomes.

Los Angeles, California
NCT06852222Recruiting· Phase 3
Study of bleximenib, venetoclax, and azacitidine for newly diagnosed AML

This trial tests a new drug combination (bleximenib, venetoclax, and azacitidine) for people with a specific genetic type of AML who cannot receive strong chemotherapy. The goal is to see if this combination is safer and more effective.

Birmingham, Alabama
NCT07623187Not yet recruiting· Phase 2/Phase 3
Study of a new drug combined with standard therapy for acute myeloid leukemia

This trial tests whether adding a new medicine (IPN60340) to the usual two-drug combo (azacitidine and venetoclax) helps people with newly diagnosed acute myeloid leukemia (AML) who are not able to receive intensive chemotherapy. It may offer a more effective treatment option for those who cannot tolerate stronger chemotherapy.

Hear when a new ACUTE MYELOID LEUKEMIA; AML trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.