Azacitidine and venetoclax for people with AML in remission
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a combination of two drugs, azacitidine and venetoclax, for people with acute myeloid leukemia (AML) who have achieved remission after initial chemotherapy but still have tiny amounts of leukemia cells left (measurable residual disease). The goal is to see if this treatment can clear those remaining cells before a stem cell transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with AML (not APL type) and have received 1 to 3 rounds of intensive chemotherapy.
- Your leukemia is in remission, meaning less than 5% blast cells in your bone marrow.
- You still have measurable residual disease (MRD) at a specific level detected by flow cytometry or PCR.
- You are healthy enough for more intensive chemotherapy and a stem cell transplant.
- Your liver and kidney function are within safe limits, and you do not have active infections or serious heart disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests whether the combination of venetoclax and azacitidine can clear small amounts of leukemia cells that remain after initial chemotherapy (called measurable residual disease or MRD). It is for people with acute myeloid leukemia who have MRD before a stem cell transplant.
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