Psilocybin vs Ketamine for Alcohol Use Disorder Trial
Treatments studied
Part of Mental health clinical trials.
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have moderate to severe alcohol use disorder (AUD) and have had at least 4 heavy drinking days (5+ drinks per day) in the past month.
- You are not currently in formal AUD treatment and weigh between 110 and 330 pounds (50–150 kg).
- You have no history of seizures, heart problems, uncontrolled high blood pressure, diabetes (insulin-dependent), pancreatitis, liver disease, or serious head injury in the last 2 years.
- You have not used hallucinogens (like psilocybin) or ketamine in the past 12 months, and you don't have a personal or family history of psychotic disorders (like schizophrenia).
- You can provide a family member or friend to pick you up and stay with you overnight after each drug session.
- You are not currently taking certain medications (e.g., antidepressants, antipsychotics, benzodiazepines, or any drug that could interact with the study drugs) unless approved by the study team.
- You have no MRI-incompatible devices (e.g., pacemaker) and for women able to become pregnant, you must not be pregnant or nursing and use contraception.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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