Psilocybin vs Ketamine for Alcohol Use Disorder Trial
Treatments studied
Part of Mental health clinical trials.
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have moderate to severe alcohol use disorder (AUD) and have had at least 4 heavy drinking days (5+ drinks per day) in the past month.
- You are not currently in formal AUD treatment and weigh between 110 and 330 pounds (50–150 kg).
- You have no history of seizures, heart problems, uncontrolled high blood pressure, diabetes (insulin-dependent), pancreatitis, liver disease, or serious head injury in the last 2 years.
- You have not used hallucinogens (like psilocybin) or ketamine in the past 12 months, and you don't have a personal or family history of psychotic disorders (like schizophrenia).
- You can provide a family member or friend to pick you up and stay with you overnight after each drug session.
- You are not currently taking certain medications (e.g., antidepressants, antipsychotics, benzodiazepines, or any drug that could interact with the study drugs) unless approved by the study team.
- You have no MRI-incompatible devices (e.g., pacemaker) and for women able to become pregnant, you must not be pregnant or nursing and use contraception.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
This study tests whether a therapy that uses a psychedelic substance called psilocybin (a hallucinogen) can help people with severe alcohol problems. You would receive it in a supervised setting along with talk therapy, with the goal of helping you cut back or stop drinking.
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
This trial tests whether psilocybin (the active ingredient in magic mushrooms), given with talk therapy, can help people who want to reduce their heavy drinking. It is for people with at least moderate alcohol use disorder who are motivated to change.
Hear when a new Alcohol Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.