Ketamine and therapy for alcohol use disorder and depression
Treatments studied
Part of Mental health clinical trials.
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have alcohol use disorder and depression that hasn't gotten better after trying at least 2 different treatments.
- You need to be willing to attend 8 weekly therapy sessions and keep your current medications unchanged.
- Your drinking level must be at least moderate – for men, more than about 3 drinks a day, and for women, more than about 1.5 drinks a day.
- You must agree to avoid grapefruit juice on ketamine infusion days and not drive or use heavy machinery for 24 hours after each infusion.
- You cannot be pregnant, breastfeeding, or have certain health problems like severe high blood pressure, liver or kidney issues, or a history of head injury.
- You cannot use benzodiazepines, narcotics, or specific medications (like memantine or lamotrigine) within 12 hours before each infusion.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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